PhotoCorrect 415 Laser Bio-Stimulation for Acne. The principle treatment for acne and dermatological therapy including: Methicillin-Resistant Staphylococcus aureus (MRSA) -Staph infections
Destroy P.Acne Bacteria
Device Summary Photoorrect 415D laser uses unprecedented 405nm and 415nm wavelengths to target and absorb porphyrins in acne related skin. These specific wavelengths successfully penetrate the Dermis and activates porphyrins (Coproporphyrin III) in Propionibacterium acnes (P. Acnes) which generate free radicals damaging and ultimately killing the bacteria by releasing singlet oxygen. This high energy photodynamic therapy results in a direct elimination of P. acnes and highest rate of absorption of porphyrins in acne, significantly brightening the skin and improving its’ texture.
The Science, Engineering & Technology
The most common acne condition is P.acnes it can occur on the face, chest, back, and shoulders. It is caused by many factors. The root cause is the abnormal development of cells inside the hair follicles in the skin, which leads to the clogging of hair follicles, excess production of oil (or sebum), and accumulation of bacteria. These bacteria build-up causing inflammation and pain. PhotoCorrect 415 blue laser treats mild to moderately severe acne and can be more effective in treating acne than the traditional topical acne solutions such as benzoyl peroxide and salicylic acid. Laser acne results can be noticeable after three sessions.
No Side Effects and No burning
The PhotoCorrect 415 laser modality utilizes high intensity blue light therapy which is most effective in destroying acne bacteria. This blue light energy is effective for acne treatment, inducing photodynamic destruction of Propionibacterium acnes (P. acnes). PhotoCorrect 415 laser’s blue light therapy does not damage the skin or have negative side effects, the light energy is within such a small band of the electromagnetic spectrum, other tissues and cells (like skin) are not damaged.
Clear Complexion and Pimple Free
PhotoCorrect 415 therapy offers a treatment for a clearer complexion and pimple free skin. Improving overall well being and appearance for years to come. Compared to other lasers our specific modality is the optimal solution for patients with acne whom are affected emotionally, socially and physically. PhotoCorrect 415 is the only laser available which applies a dual wavelength of 405nm & 415nm making for a more advanced effective acne laser treatment.
PhotoCorrect 415 laser therapy offers a non invasive treatment solution with no use of anesthesia, gels, creams, numbing agents, needles and no downtime. It is safe, pain free, affordable and comfortable. These treatments can be used in conjunction with other treatments. Results are cumulative and a treatment series is typically recommended for maximum benefits. Follow up treatments are suggested for maintaining the results achieved and avoiding future break outs. Make PhotoCorrect 415 laser therapy part of your skin care regimen.
Clinical Studies and Extracts of Studies
Summary of Technology and Benefits
British Journal of Dermatology 2000; 142: 973+978.
Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris
In this study we have evaluated the use of blue light (peak at 415 nm) and a mixed blue and red light (peaks at 415 and 660 nm) in the treatment of acne vulgaris. One hundred and seven patientswith mild to moderate acne vulgaris were randomized into four treatment groups: blue light, mixed blue and red light, cool white light and 5% benzoyl peroxide cream. Subjects in the phototherapy groups used portable light sources and irradiation was carried out daily for 15 min. Comparative assessment between the three light sources was made in an observer-blinded fashion, but this could not be achieved for the use of benzoyl peroxide. Assessments were performed every 4 weeks. After 12 weeks of active treatment a mean improvement of 76% (95% confidence interval 66+87) in inflammatory lesions was achieved by the combined blue+red light phototherapy; this was significantly superior to that achieved by blue light (at weeks 4 and 8 but not week 12), benzoyl peroxide (at weeks 8 and 12) or white light (at each assessment). The final mean improvement in comedones by using blue+red light was 58% (95% confidence interval 45+71), again better than that achieved by the other active treatments used, although the differences did not reach significant levels. We have found that phototherapy with mixed blue+red light, probably by combining antibacterial and anti-inflammatory action, is an effective means of treating acne vulgaris of mild to moderate severity, with no significant short-term adverse effects. Key words: acne, blue+red light, phototherapy
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light
Helena Ashkenazi a, Zvi Malik a, Yoram Harth b, Yeshayahu Nitzan
Health Sciences Research Center, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel b Elisha Medical Center, Haifa, Israel
Received 11 February 2002; received in revised form 4 July 2002; accepted 24 July 2002 First published online 2 November 2002
Propionibacterium acnes is a Gram-positive, microaerophilic bacterium that causes skin wounds. It is known to naturally produce high amounts of intracellular porphyrins. The results of the present study confirm that the investigated strain of P. acnes is capable of producing endogenic porphyrins with no need for any trigger molecules. Extracts from growing cultures have demonstrated emission peaks around 612 nm when excited at 405 nm, which are characteristic for porphyrins. Endogenic porphyrins were determined and quantified after their extraction from the bacterial cells by fluorescence intensity and by elution retention time on high-performance liquid chromatography (HPLC). The porphyrins produced by P. acnes are mostly coproporphyrin, as shown by the HPLC elution patterns. Addition of N-aminolevulinic acid (ALA) enhanced intracellular porphyrin synthesis and higher amounts of coproporphyrin have been found. Eradication of P. acnes by its endogenic porphyrins was examined after illumination with intense blue light at 407^420 nm. The viability of 24 h cultures grown anaerobically in liquid medium was reduced by less than two orders of magnitude when illuminated once with a light dose of 75 J cm32. Better photodynamic effects were obtained when cultures were illuminated twice or three times consecutively with a light dose of 75 J cm32 and an interval of 24 h between illuminations. The viability of the culture under these conditions decreased by four orders of magnitude after two illuminations and by five orders of magnitude after three illuminations. When ALA-triggered cultures were illuminated with intense blue light at a light dose of 75 J cm32 the viability of the treated cultures decreased by seven orders of magnitude. This decrease in viability can occur even after a single exposure of illumination for the indicated light intensity. X-ray microanalysis and transmission electron microscopy revealed structural damages to membranes in the illuminated P. acnes. Illumination of the endogenous coproporphyrin with blue light (407^420 nm) apparently plays a major role in P. acnes photoinactivation. A treatment protocol with a series of several illuminations or illumination after application of ALA may be suitable for curing acne. Treatment by both pathways may overcome the resistance of P. acnes to antibiotic treatment. < 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Keywords:Endogenic porphyrins; Phototreatment of acne; Illumination by blue light; Photoeradication; Acne; Propionibacterium acnes Bumah VV, Masson-Meyers DS, Cashin SE, Enwemeka CS.
Source 1 College of Health Sciences, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin.
Wavelength and Bacterial Density Influence the Bactericidal Effect of Blue Light on Methicillin-Resistant Staphylococcus aureus (MRSA).
Abstract Objective:The purpose of this study was to investigate the effect of wavelength and methicillin-resistant Staphylococcus aureus (MRSA) density on the bactericidal effect of 405 and 470?nm light. Background data: It is recognized that 405 and 470?nm light-emitting diode (LED) light kill MRSA in standard 5*106 colony-forming units (CFU)/mL cultures; however, the effect of bacterial density on the bactericidal effect of each wavelength is not known. Methods: In three experiments, we cultured and plated US300 MRSA at four densities. Then, we irradiated each plate once with either wavelength at 0, 1, 3, 45, 50, 55, 60, and 220?J/cm2. Results: Irradiation with either wavelength reduced bacterial colonies at each density (p0.05). More bacteria were cleared as density increased; however, the proportion of colonies cleared, inversely decreased as density increased-the maximum being 100%, 96%, and 78% for 3*106, 5*106, and 7*106 CFU/mL cultures, respectively. Both wavelengths had similar effects on the sparser 3*106 and 5*106 CFU/mL cultures, but in the denser 7*106 CFU/mL culture, 405?nm light cleared more bacteria at each fluence (p < 0.001). To determine the effect of beam penetration, denser 8*106 and 12*106 CFU/mL culture plates were irradiated either from the top, the bottom, or both directions. More colonies were eradicated from plates irradiated from top and bottom, than from plates irradiated from top or bottom at the same sum total fluences (p< 0.001). Conclusions: The bactericidal effect of LED blue light is limited more by light penetration of bacterial layers than by bacterial density per se.
The PhotoCorrect 415 laser effect
The PhotoCorrect 415 Laser features
1. Our blue light energy is absorbed by specific molecules within this species of bacteria. These specific molecules are called porphyrins and Propionibacterium acnes (P. acnes) produces an inordinate number of these molecules. When porphyrins are stimulated by blue light energy, they are disrupted, and the Propionibacterium acnes dies.
2. The light energy is within such a small band of the electromagnetic spectrum, other tissues and cells (like skin) are not damaged.
3. By killing these acne-causing bacteria, inflammatory acne skin lesions decrease by about two-thirds, on average. In other words about 66% of acne improved on the patients face.
4. More impressively, skin that was successfully treated with 405nm & 415nm light therapy remained acne free for at least eight weeks after the end of therapy.
5. Light therapy in the blue band of the electromagnetic spectrum was as effective or more effective as the skin cream, benzoyl peroxide, at treating P.acne grades II and III acne (out of four grades; grade III is considered severe). The blue light is able to kill Porphyrins due to the high affinity with the dual wavelength. The blue light has a calming action which is very effective for hypersensitivity.
6. Results are cumulative and a treatment series is typically recommended for maximum benefits. Follow up treatments are suggested for maintaining results achieved
7. Consistent laser output for quality treatments throughout the day.
8. PhotoCorrect 415 laser blue light therapy was associated with fewer side effects than the traditional topical therapy, such as burning, itching and dryness of the skin.
Before And After
Easy Snap on /off panel, for Customized Fat Targeting and Body Contouring
Wavelength(s): 405nm and 415nm
Power output: 10mw
Laser Delivery: Direct from source